Stability of Insulin on Polycaprolactone Nanoparticles as a Function of Surface Properties

The purpose of this research was to formulate insulin-loaded polycaprolactone (PCL) nanoparticles and evaluate structural stability the protein using fluorescence spectroscopy. size morphology were characterized dynamic light scattering (DLS) scanning electron microscopy (SEM). Fluorescence emission data revealed that insulin is most stable with multilayer adsorption at pH close its isoelectric point (IEP). obtained particle ranged from 130-140 nm+22 (SD). loading amount onto PCL low 7.4 relatively high 5.3. phenomenon hydrophobic provides a promising noninvasive carrier system for insulin.